Jennifer Ogren, Ph.D.
Department of Neurobiology 10833 Le Conte Avenue, Rm 73-210 CHS Los Angeles, CA 90095-1763 Campus Mail Code 176318
Dr. Ogren oversees acquisition of electrophysiological and structural MRI data from epilepsy patients at risk for sudden unexpected death in epilepsy (SUDEP), a condition which is responsible for ~5,000 deaths/yr in the U.S. UCLA recently received one of five NIH UO1 awards to institutions in the U.S. and UK to examine electroclinical, autonomic, respiratory, sleep, genetic, and pathological substrates of seizure-driven autonomic and respiratory dysregulation in epilepsy. She will evaluate the patho-physiology of baseline and seizure-related EEG, autonomic and respiratory patterns to identify the nature of those patterns during seizure discharge that may lead to SUDEP within the population with intractable epilepsy, and relate those patterns to MRI-determined magnitude and laterality of gray and white matter abnormalities, especially in autonomic and respiratory regulatory sites. Dr. Ogren obtained her initial training with the Epilepsy group at UCLA, and has successfully conducted studies in this population. She has related MRI-based morphological changes to electrophysiological and fMRI signals, and evaluated the consequences of temporal lobe injury to distorted function in other autonomic brain areas. Her efforts as Co-Investigator on this project are essential for analysis to describe morphologic tissue loss in epilepsy, and relating those aspects to the electrophysiological findings.